Journal
JOURNAL OF NEUROSCIENCE
Volume 24, Issue 44, Pages 9862-9869Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3446-04.2004
Keywords
alcoholism; calcium channel; conotoxin; conditioned place preference; ethanol preference; knock-out
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Funding
- NIAAA NIH HHS [R37 AA013588, R01 AA008117] Funding Source: Medline
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N-type calcium channels are modulated by acute and chronic ethanol exposure in vitro at concentrations known to affect humans, but it is not known whether N-type channels are important for behavioral responses to ethanol in vivo. Here, we show that in mice lacking functional N-type calcium channels, voluntary ethanol consumption is reduced and place preference is developed only at a low dose of ethanol. The hypnotic effects of ethanol are also substantially diminished, whereas ethanol-induced ataxia is mildly increased. These results demonstrate that N-type calcium channels modulate acute responses to ethanol and are important mediators of ethanol reward and preference.
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