4.5 Article

Metal triflate-catalyzed one-pot synthesis of α-aminophosphonates from carbonyl compounds in the absence of solvent

Journal

SYNTHESIS-STUTTGART
Volume -, Issue 16, Pages 2692-2696

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-2004-831251

Keywords

alpha-aminophosphonates; imines; diethyl phosphate; metal triflates; solvent free; aldehydes; ketones; amines

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A simple and general method has been developed for one-pot three-component synthesis of alpha-aminophosphonates catalyzed by several metal triflates [M(OTf)(n), M = Li, Mg, Al, Cu, Ce] in the absence of solvent in good to high yields.

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