Journal
ONCOGENE
Volume 23, Issue 52, Pages 8520-8526Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1207892
Keywords
DKK1; Wnt; beta-catenin; TCF; TCF-binding element; negative feedback
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Wnt signaling plays an important role in embryonic development and tumorigenesis. These biological effects are exerted by activation of the beta-catenin/TCF transcription complex and consequent regulation of a set of downstream genes. TCF-binding elements have been found in the promoter regions of many TCF target genes and characterized by a highly conserved consensus sequence. Utilizing this consensus sequence, we performed an in silico screening for new TCF target genes. Through computational screening and subsequent experimental analysis, we identified a novel TCF target gene, DKK1, which has been shown to be a potent inhibitor of Wnt signaling. Our finding suggests the existence of a novel feedback loop in Wnt signaling.
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