Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 47, Issue 23, Pages 5616-5619Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm049793g
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Small molecule protein kinase inhibitors are widely employed as biological reagents and as leads in the design of drugs for a variety of diseases. One of the hardest challenges in kinase inhibitor design is achieving target selectivity. By utilizing X-ray structural information for four promiscuous inhibitors, we propose a five-point pharmacophore for kinase frequent hitters, demonstrate its ability to discriminate between frequent hitters and selective ligands, and suggest a strategy for selective inhibitor design.
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