Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 101, Issue 45, Pages 16034-16039Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0404686101
Keywords
virus; neuron
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Funding
- NIAID NIH HHS [R01 AI056346, 1R01 AI 056346] Funding Source: Medline
- NIGMS NIH HHS [R01 GM064624, 1R01 GM 64624] Funding Source: Medline
- NINDS NIH HHS [1F32 NS 042967-01A1, F32 NS042967] Funding Source: Medline
- PHS HHS [1R01 33506] Funding Source: Medline
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The core structures of many viruses move within cells by association with host cytoskeletal motor proteins; however, the mechanisms by which intracellular viral particles are transported toward sites of replication or the cell periphery at distinct stages of infection remain to be understood. The regulation of herpesvirus directional transport in sensory neurons was examined by tracking individual viral capsids within axons at multiple frames per s. After entry into axons, capsids underwent bidirectional and saltatory movement to the cell body independently of endosomes. A comparison of entry transport to a previous analysis of capsid axonal transport during egress revealed that capsid targeting in and out of cells occurs by modulation of plus-end, but not minus-end, motion. Entry transport was unperturbed by the presence of egressing virus from a prior infection, indicating that transport direction is not modulated globally by viral gene expression, but rather directly by a component of the viral particle.
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