Journal
JOURNAL OF NEUROSCIENCE
Volume 24, Issue 45, Pages 10099-10102Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2680-04.2004
Keywords
Alzheimer; Down syndrome; gene; Huntington; memory; morphometry; neurotrophic; schizophrenia; BDNF; voxel-based; VBM; imaging genomics
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A variation in the BDNF gene ( val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of in brain morphology related to learning and memory.
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