4.8 Article

Rhodium-catalyzed novel trifluoromethylation at the α-position of α-β-unsaturated ketones

Journal

ORGANIC LETTERS
Volume 6, Issue 23, Pages 4359-4361

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol048134v

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Treatment of alpha,beta-unsaturated ketones with CF3I in the presence of Et2Zn and RhCl(PPh3)(3) gave novel alpha-trifluoromethylation products in good yields. Hydrogen transfer from the ethyl group on the rhodium complex to the beta-position of the enone seems to play an important role in this reaction.

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