Journal
ORGANIC LETTERS
Volume 6, Issue 23, Pages 4363-4366Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol0481129
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The addition of acylsilanes to imines catalyzed by neutral carbenes (or zwitterions) generated in situ from readily available thiazolium salts is described. The general reaction successfully utilizes acylsilanes as carbonyl anion precursors and is tolerant of a range of structural diversity on the acylsilane or imine electrophile. The overall reaction utilizes easily available precursors and directly accesses protected alpha-amino ketones in the correct oxidation state.
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