Journal
CIRCULATION RESEARCH
Volume 95, Issue 10, Pages 957-970Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.RES.0000148632.35500.d9
Keywords
apoptosis; necrosis; cell death; mitochondria; Bcl-2; caspase; death inducing signaling complex; apoptosome; ischemia; heart failure
Funding
- NHLBI NIH HHS [HL60665, R01S HL73935, HL61550] Funding Source: Medline
- NIGMS NIH HHS [T32 GM07491] Funding Source: Medline
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Apoptosis has been causally linked to the pathogenesis of myocardial infarction and heart failure in rodent models. This death process is mediated by two central pathways, an extrinsic pathway involving cell surface receptors and an intrinsic pathway using mitochondria and the endoplasmic reticulum. Each of these pathways has been implicated in myocardial pathology. In this review, we summarize recent advances in the understanding of the intrinsic pathway and how it relates to cardiac myocyte death and heart disease.
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