Journal
EXPERIMENTAL CELL RESEARCH
Volume 301, Issue 1, Pages 60-67Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2004.08.016
Keywords
aurora kinase; mitosis; centrosome; spindle; chromosome segregation; centromere; kinetochore
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The Aurora kinase family consists of three members, Aurora A, B, and C. The Aurora A and B kinases have emerged as essential regulators of cell division. While Aurora A kinase is implicated in regulating mitotic entry, centrosome maturation, and spindle assembly, Aurora B is required for correct chromosome segregation and cytokinesis. In this review, we summarize the roles of Aurora A and B in spindle assembly and chromosome segregation. (C) 2004 Published by Elsevier Inc.
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