Journal
TETRAHEDRON
Volume 60, Issue 47, Pages 10739-10745Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2004.08.091
Keywords
alkaloids; NMR; plants
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The leaf extract of the Borneo Kopsia, K. tennis, provided several new indoles with a novel hexacyclic carbon skeleton, incorporating a cyclopropyl moiety. Two of these, displayed appreciable in vitro cytotoxicity against B16 melanoma cells, as well as the circumvention of drug-resistance in drug-resistant KB cells. The structures of tenuisines A-C were revised from a dimeric to a monomeric structure, based on new LSIMS data, and in conjunction with the preparation of the methyl iodide salt of tenuisine A. (C) 2004 Elsevier Ltd. All rights reserved.
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