Journal
NEUROREPORT
Volume 15, Issue 16, Pages 2467-2470Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200411150-00007
Keywords
diffusion tensor imaging; impulsivity; schizophrenia
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Funding
- NIMH NIH HHS [K02 MH001439, R01 MH66374, R37 MH49334, R01 MH064783, K02 MH01439, R01 MH60662, R01 MH060662, R01 MH066374, R37 MH049334] Funding Source: Medline
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Compromised white matter (WM) integrity in inferior frontal WM has been related to impulsivity in men with schizophrenia. However, these relationships may be more widespread. Fractional anisotropy (FA) derived from diffusion tensor imaging of 25 men with schizophrenia was transformed into Talairach space. Correlations between FA and impulsiveness were examined on a voxelwise basis. We found negative correlations between FA and impulsivity in inferior frontal WM, anterior cingulate, caudate, insula, and inferior parietal lobule. Positive correlations were obtained in the left postcentral gyrus, right superior/middle temporal gyrus, and bilateral fusiform gyrus. These areas may comprise a fronto-temporo-limbic circuit that modulates impulsivity. The voxelwise correlation method can serve as a hypothesis-generation method for relating target behaviors to their underlying neural networks.
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