Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 689, Issue 23, Pages 3778-3781Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2004.06.045
Keywords
palladium catalysed Heck-couplings using ball-mill grinding
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The synthesis of unsaturated unnatural amino acids according to the Heck-Jeffery protocol using a ball-milling procedure is presented. NOE data recorded on the products confirm that the Z-isomer is formed. This type of mechano-chemistry provides an efficient, solvent free and reliable method for the synthesis of substituted dehydroalanines. These conditions provide patterns of reactivity complementary to conventional procedures. (C) 2004 Elsevier B.V. All rights reserved.
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