Journal
NEUROSCIENCE LETTERS
Volume 371, Issue 1, Pages 6-11Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2004.07.034
Keywords
insulin degrading enzyme (insulysin); cerebral endothelium; A beta catabolism
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Insulin degrading enzyme (IDE) is found in the cytosol, peroxisomes and plasma membrane of many cells. Although it preferentially cleaves insulin it can also cleave many other small proteins with diverse sequences including the monomeric form of the amyloid beta peptide (Abeta). In the brain, IDE has been reported to be expressed predominantly in neurons. In this study, IDE expression was detected in cultured human cerebrovascular endothelial cells. Using laser capture microdissection followed by PCR analysis, it was found that IDE mRNA is expressed in human brain blood vessels. Using immunofluorescence and multiphoton microscopy IDE was localized to the endothelium of the cerebrovascular blood vessels in human. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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