Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 47, Issue 24, Pages 6042-6054Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm049937r
Keywords
-
Categories
Ask authors/readers for more resources
Sesquiterpene lactones (SLs) are the active compounds of a variety of tradionally used medicinal plants from the Asteraceae family. They are known to possess a considerable antiinflammatory activity in different inflammation models. They inhibit the transcription factor NF-kappaB probably by alkylating cysteine38 in the DNA binding domain of the p65 subunit. Here we investigate a set of 103 different sesquiterpene lactones representing 6 structural groups (44 germacranolides, 16 heliangolides, 22 guaianolides, 9 pseudoguaianolides, 2 hypocretenolides, 10 eudesmanolides) for their NF-kappaB inhibiting properties and the resulting IC100-values were submitted to a QSAR study. Properties important for the inhibition potency are discussed for the whole data set and for subsets of the different structural classes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available