4.4 Article

An environmentally benign and practical synthesis of sugar orthoesters promoted by potassium fluoride

Journal

TETRAHEDRON LETTERS
Volume 45, Issue 48, Pages 8847-8848

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.09.175

Keywords

sugar orthoesters; potassium fluoride; glycosyl bromides

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An extremely practical method for synthesis of sugar orthoesters has been developed without using any organic amines or heavy metals as additives. Various sugar orthoesters were prepared in good yields by the reaction of an acylated glycosyl bromide and an alcohol in the presence of potassium fluoride. (C) 2004 Elsevier Ltd. All rights reserved.

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