Journal
TETRAHEDRON LETTERS
Volume 45, Issue 48, Pages 8831-8834Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.10.008
Keywords
Fischer indole synthesis; microwaves; solid support; 2-heteroaryl-5-methoxyindoles; sempervirine type methoxy analogues
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A general protocol for the synthesis of 2-heteroaryl-5-methoxyindoles has been developed utilizing a microwave-induced solid-supported Fischer indolization under controlled conditions This route uses 2-acetylpyridine as a model and 3-acetyl derivatives of cycloalkeno[c]fused pyridines as the synthetic building blocks towards new 9-methoxyindolo[2,3-a]quinolizine alkaloids. (C) 2004 Elsevier Ltd. All rights reserved.
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