Journal
JOURNAL OF THE ROYAL SOCIETY INTERFACE
Volume 1, Issue 1, Pages 91-97Publisher
ROYAL SOC
DOI: 10.1098/rsif.2004.0010
Keywords
magnetic twisting cytometry; creep compliance; cell mechanics; elasticity; soft glassy rheology
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Funding
- NHLBI NIH HHS [HL 59682, HL 33009] Funding Source: Medline
- NIAID NIH HHS [HL/AI 65960] Funding Source: Medline
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We report here the creep function measured in three cell types, after a variety of interventions, and over three time decades (from 3 ms to 3.2 s). In each case the response conformed to a power law, implying that no distinct molecular relaxation times or time constants could characterize the response. These results add to a growing body of evidence that stands in contrast to widely used viscoelastic models featuring at most a few time constants. We show instead that the ability of the matrix to deform is time-scale invariant and characterized by only one parameter: the power law exponent that controls the transition between solid-like and liquid-like behaviour. Moreover, we validate linearity by comparison of measurements in the time and frequency domains.
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