Journal
NATURE
Volume 432, Issue 7016, Pages 522-525Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature03035
Keywords
-
Categories
Ask authors/readers for more resources
Eukaryotic protein-encoding genes possess poly(A) signals that define the end of the messenger RNA and mediate downstream transcriptional termination by RNA polymerase II (Pol II)(1). Termination could occur through an 'anti-termination' mechanism whereby elongation factors dissociate when the poly(A) signal is encountered, producing termination-competent Pol II2,3. An alternative 'torpedo' model postulated that poly(A) site cleavage provides an unprotected RNA 5' end that is degraded by 5' --> 3' exonuclease activities ( torpedoes) and so
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available