4.8 Article

Asymmetric synthesis of cis-5-substituted pyrrolidine 2-phosphonates using metal carbenoid NH insertion and β-amino β-ketophosphonates

Journal

ORGANIC LETTERS
Volume 6, Issue 24, Pages 4523-4525

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol048157+

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Funding

  1. NIGMS NIH HHS [GM 57870] Funding Source: Medline

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Cis-5-substituted pyrrolidine phosphonates, proline surrogates, are prepared by a highly stereoselective intramolecular metal carbenoid N-H insertion from a sulfinimine-derived delta-amino alpha-diazo beta-ketophosphonate.

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