Journal
BRAIN RESEARCH
Volume 1028, Issue 1, Pages 116-119Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2004.08.066
Keywords
ErbB4; microdialysis; nigrostriatal pathway; rodent
Categories
Funding
- NINDS NIH HHS [NS39128] Funding Source: Medline
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Previous studies have provided anatomical evidence that the functional neuregulin receptor, ErbB4, is present within the ventral midbrain where it is co-localized to dopamine neurons of the substantia nigra and ventral tegmental area. In this study, we provide evidence that neuregulinl-beta (a.k.a. heregulinl-beta), a neuregulin-1 gene isoform that preferentially binds to and activates the ErbB4 receptor, evokes an almost immediate overflow of striatal dopamine when injected into a region just dorsal to the ipsilateral substantia nigra. These data are indicative that neuregulins can modulate the activity of mesostriatal dopaminergic neurons. (C) 2004 Elsevier B.V. All rights reserved.
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