Journal
CIRCULATION RESEARCH
Volume 95, Issue 11, Pages 1075-1081Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.RES.0000149564.49410.0d
Keywords
Cu/Zn-superoxide dismutase; catalase; atherosclerosis; F-2-isoprostanes
Funding
- NHLBI NIH HHS [HL071525, K01 HL076623, HL076623] Funding Source: Medline
- NIGMS NIH HHS [GM08037, S06 GM008037] Funding Source: Medline
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Oxidative stress has been suggested to potentiate atherogenesis. However, studies that have investigated the effect of antioxidants on atherosclerosis showed inconsistent results, ie, atherosclerosis was either retarded or not changed by dietary antioxidants. This report directly examined the effect of overexpressing Cu/Zn-superoxide dismutase (Cu/Zn-SOD) and/or catalase on atherosclerosis and lipid peroxidation in mice lacking apolipoprotein E (ApoE(-/-)). Based on lipid staining of the en face of the aorta tree and the serial sections of the proximal aorta, ApoE(-/-) mice overexpressing catalase or both Cu/Zn-SOD and catalase had smaller and relatively early stages of atherosclerotic lesions (eg, foam cells and free lipids) when compared with ApoE(-/-) mice, who developed more advanced lesions (eg, fibrous caps and acellular areas). In addition, the retarded development of atherosclerosis was correlated with a reduced F-2-isoprostanes in the plasma and aortas in ApoE(-/-) mice overexpressing catalase or both Cu/Zn-SOD and catalase. In contrast, the levels of F-2-isoprostanes and atherosclerosis in the ApoE(-/-) mice overexpressing Cu/Zn-SOD alone were comparable to ApoE(-/-) control mice. These observations implied that endogenously produced hydrogen peroxide, but not superoxide anions, contributed to the formation of oxidized lipids and the development of atherosclerosis in ApoE(-/-) mice.
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