Journal
SCIENCE
Volume 306, Issue 5701, Pages 1547-1550Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1101786
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Funding
- NIAID NIH HHS [R43 AI050321, R43 AI057068] Funding Source: Medline
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Reproductive strategies such as sexual reproduction and recombination that involve the shuffling of parental genomes for the production of offspring are ubiquitous in nature. However, their evolutionary benefit remains unclear. Many theories have identified potential benefits, but progress is hampered by the scarcity of relevant data. One class of theories is based on the assumption that mutations affecting fitness exhibit negative epistasis. Retroviruses recombine frequently and thus provide a unique opportunity to test these theories. Using amino acid sequence data and fitness values from 9466 human immunodeficiency virus 1 (HIV-1) isolates, we find in contrast to these theories strong statistical evidence for a predominance of positive epistasis in HIV-1.
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