Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1695, Issue 1-3, Pages 55-72Publisher
ELSEVIER
DOI: 10.1016/j.bbamcr.2004.09.019
Keywords
E1; E2; E3; Nedd8; Sumo; Ubc; ubiquitin
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Ubiquitin is the founding member of a family of structurally conserved proteins that regulate a host of processes in eukaryotic cells. Ubiquitin and its relatives carry out their functions through covalent attachment to other cellular proteins. thereby changing the stability, localization, or activity of the target protein. This article reviews the basic biochemistry of these protein conjugation reactions. focusing on ubiquitin itself and emphasizing recent insights into mechanism and specificity. (C) 2004 Elsevier B.V. All rights reserved.
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