Journal
INFECTION AND IMMUNITY
Volume 72, Issue 12, Pages 7352-7356Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.72.12.7352-7356.2004
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The role of immunity in blinding trachoma is unclear. Conjunctival gene expression was measured in a population where trachoma is endemic. Proinflammatory (tumor necrosis factor alpha and interleukin-1beta [IL-1beta]), anti-inflammatory (IL-10), and fibrogenic (matrix metalloprotease 9) gene expression was increased in active trachoma. Markers indicative of T-cell response (gamma interferon, IL-4, IL-12p40, and perforin) were increased when chlamydial infection was present.
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