Journal
APPLIED PHYSICS LETTERS
Volume 94, Issue 18, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.3126452
Keywords
biochemistry; biological effects of ionising particles; biomolecular effects of radiation; cancer; cellular effects of radiation; DNA; dosimetry; laser applications in medicine; particle beam bunching; proton effects; radiation therapy; tumours
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Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
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We report the demonstrated irradiation effect of laser-accelerated protons on human cancer cells. In vitro (living) A549 cells are irradiated with quasimonoenergetic proton bunches of 0.8-2.4 MeV with a single bunch duration of 15 ns. Irradiation with the proton dose of 20 Gy results in a distinct formation of gamma-H2AX foci as an indicator of DNA double-strand breaks generated in the cancer cells. This is a pioneering result that points to future investigations of the radiobiological effects of laser-driven ion beams. Unique high-current and short-bunch features make laser-driven proton bunches an excitation source for time-resolved determination of radical yields.
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