Journal
BIOLOGICAL PSYCHIATRY
Volume 56, Issue 11, Pages 819-824Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2004.02.009
Keywords
immune system; cytokines; interferon-alpha; mood disorders; depression; pathophysiology
Categories
Funding
- NIMH NIH HHS [MH60723, MH00680] Funding Source: Medline
Ask authors/readers for more resources
Inteiferon-alpha is a potent inducer of the cytokine network and is notorious jbr causing behavioral alterations. Studies on inteiferon-alpha-treated patients reveal at least two distinct syndromes: 1) a mood/cognitive syndrome that appears late during interferon-alpha therapy is responsive to antidepressants and is associated with activation of neuroendocrine pathways and altered serotonin metabolism,: and 2) a neurovegetative syndrome characterized by pychomotor slowing, and fatigue that appears early during inteiferon-alpha treatment is antidepressant nonresponsive and may be mediated by alterations in basal ganglia dopamine metabolism. Findings from inteferon-alpha may provide important clues regarding, the pathophysiology and treatment of cytokine-induced behavioral changes in medically ill patients, while also potentially modeling the development of neuropsychiatric symptoms in patients without medical disordcrs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available