Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 48, Issue 12, Pages 4873-4877Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.48.12.4873-4877.2004
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- NIAID NIH HHS [AI33537, R01 AI033537] Funding Source: Medline
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Expression of the bla1 and bla2 genes in an archetypal Bacillus anthracis strain is insufficient for penicillin resistance. In a penicillin-resistant clinical isolate, both genes are highly transcribed, but bla1 is the major contributor to high-level resistance to ampicillin. Differential expression of the bla genes is dependent upon strain background.
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