Journal
APPLIED PHYSICS LETTERS
Volume 94, Issue 3, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.3073749
Keywords
biological tissues; biomedical optical imaging; biomedical ultrasonics; eye; laser applications in medicine; patient diagnosis; photoacoustic effect; ultrasonic transducers
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Funding
- NIH [P41-EB002182]
- Clinical and Translational Science Center at Weill Cornell Medical College [UL1 RR024996]
- Dyson Foundation
- Riverside Research Institute
- National Center for Research Resources [RR03037]
- National Institutes of Health
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We report a photoacoustic imager that utilizes a focused laser beam in combination with a 20 MHz ultrasound focusing transducer to obtain micron-resolution tissue images over a long working distance. The imager is based on a ring transducer that combines ultrasonic and laser beams collinearly and confocally in a monolithic element. The combination of focused laser beam and short pulse irradiation led to significant improvement in lateral and axial resolutions compared to the pulse-echo ultrasonic imaging technique or photoacoustic imaging with an unfocused laser. Potential applications include clinical examination of the eye and characterization of thin and superficial tissues.
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