Journal
BEHAVIORAL NEUROSCIENCE
Volume 118, Issue 6, Pages 1418-1426Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.118.6.1418
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- NIMH NIH HHS [MH54557, MH60157] Funding Source: Medline
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Studies have shown that noxious cutaneous stimulation engages physiologically different antinociceptive systems to inhibit a spinal reflex, tail withdrawal from radiant heat. Two experiments are reported that examine the relationship between the inhibition of the tail-flick response and brain-mediated responses to nociception. The induction of a spinally mediated antinociception was accompanied by an increase in latency to vocalize to a noxious thermal stimulus, suggesting pain inhibition. Physiological manipulations that eliminated the inhibition of the tail-flick reflex restored vocalization to thermal stimulation and revealed a concurrent sensitization that generally heightened behavioral reactivity. The results suggest that net pain is regulated by 2 opposing processes, a selective inhibition of nociceptive signals within the spinal cord and a general sensitization that heightens stimulus processing.
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