Journal
EUROPEAN JOURNAL OF NEUROSCIENCE
Volume 20, Issue 11, Pages 2975-2980Publisher
WILEY
DOI: 10.1111/j.1460-9568.2004.03778.x
Keywords
Caudiverbera caudiverbera; ion channels; odour transduction
Categories
Ask authors/readers for more resources
It has previously been proposed that a Ca2+-dependent K+ conductance is implicated in the inhibitory odourant response in rat and toad olfactory receptor neurons. Previous whole-cell and single-channel measurements on inside-out excised patches, in addition to immunochemical evidence, indicated the presence of Ca2+-dependent K+ channels in olfactory cilia, the transducing structures of these sensory cells. Ca2+-dependent K+ channels opened in 'on-cilium' membrane patches from C. caudiverbera upon odourant stimulation. Furthermore, after excision in the inside-out configuration, the channel could be opened by micromolar Ca2+, in a Ca2+-dependent fashion, but it was unresponsive to cyclic AMP. We estimated that the Ca2+ concentration in the proximity of a Ca2+-dependent K+ channel within the cilia reaches at least 100 muM during the odour response. The K+ channel displayed a higher selectivity for K+ than for Na+. Our results support a role for this Ca2+-dependent K+ channel in chemotransduction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available