Journal
VISION RESEARCH
Volume 44, Issue 28, Pages 3377-3380Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.visres.2004.09.004
Keywords
ocular dominance plasticity; long-term potentiation; long-term depression; visual cortex
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Funding
- NEI NIH HHS [R01 EY11353] Funding Source: Medline
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Mechanisms of plasticity in the visual cortex have been studied with long-term potentiation (LTP), long-term depression (LTD) and ocular dominance plasticity (ODP). It is now possible to compare results from these three forms of plasticity using knockout mice, and also by pharmacological manipulations. A review of the literature shows that if both LTP and LTD are completely abolished, then ODP will also be abolished. In other situations, there is little correlation. We hypothesize that this lack of correlation occurs because the mechanisms for LTP and LTD vary with layer in the visual cortex, and results show that they do. (C) 2004 Elsevier Ltd. All rights reserved.
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