Journal
VIRUS RESEARCH
Volume 106, Issue 2, Pages 87-102Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2004.08.007
Keywords
retrovirus; L domains; multivesicular
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The release of retrovirus particles from the infected cell is greatly stimulated by short motifs, known as late or L domains, present within the Gag precursor protein. Three distinct classes of L domains have been identified; these bear the core sequence: Pro-Thr/Ser-Ala-Pro [P(T/S)AP]. Pro-Pro-x-Tyr (PPxY), or Tyr-Pro-x-Leu (YPxL). A number of recent studies have demonstrated that L domains function by interacting with components of the machinery responsible for sorting cellular proteins into the multivesicular body (MVB) pathway. This review traces the history of L domain discovery and characterization, and highlights the relationship between L domain activity, retrovirus release. and the host endosomal sorting machinery. Published by Elsevier B.V.
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