Journal
VISION RESEARCH
Volume 44, Issue 28, Pages 3389-3400Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.visres.2004.09.007
Keywords
cortical areas; extrastriate cortex; synaptic excitation; synaptic inhibition
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Funding
- NEI NIH HHS [EY05935] Funding Source: Medline
- NINDS NIH HHS [NS30676] Funding Source: Medline
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Using whole cell recordings, we studied excitatory and inhibitory postsynaptic currents (EPSCs, IPSCs) in feedforward (FF) and feedback (FB) circuits between areas VI and LM (lateromedial) in developing mouse visual cortex. We found that in mice reared with normal visual experience, FF and FB synapses onto layer 2/3 pyramidal neurons develop equal but submaximal strengths whose EPSCs are increased by monocular lid suture. In contrast, the development and experience-dependence of FF- and FB-IPSCs is pathway-specific. The difference develops during the critical period by strengthening FF-IPSCs, while keeping FB-IPSC amplitudes constant. Monocular lid suture increases FB-IPSCs but does not affect FF-IPSCs. (C) 2004 Elsevier Ltd. All rights reserved.
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