Journal
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
Volume 18, Issue 6, Pages 929-940Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.bpobgyn.2004.06.005
Keywords
differentiation; embryogenesis; human development; organogenesis; pluripotency; stem cells
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Although, the study of human development-from fertilized egg to mature embryo-is extremely important, the early differentiation of human tissues remains an enigma. Moreover, the relatively high percentage of unexplained pregnancy loss-a major concern of human embryologists and gynaecologists-emphasizes the need for an appropriate model for studying early human development. The availability of human pluripotent stem cells might allow us to study previously inaccessible basic processes that occur during human embryogenesis, such as gastrulation and organogenesis.
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