Journal
TRAFFIC
Volume 5, Issue 12, Pages 905-913Publisher
WILEY
DOI: 10.1111/j.1600-0854.2004.00234.x
Keywords
clathrin; Rab; small G protein; trypanosoma; vesicle trafficking
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Trypanosomes belong to the order kinetoplastida, an early diverging group of organisms in the eukaryotic lineage. The principal reasons for interest in these organisms are twofold; they provide a superb distant triangulation point from which to assess global features of eukaryotic biology and, more importantly, they are representative of a number of pathogenic parasitic protozoa with a huge public health impact -Trypanosoma brucei, T. cruzi and Leishmania spp. Recent advances in the study of intracellular transport in T. brucei have been considerable, and a fuller picture of the complexity, function and role that the endomembrane system plays in trypanosomes is finally emerging.
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