Journal
TRENDS IN CELL BIOLOGY
Volume 14, Issue 12, Pages 678-686Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2004.10.005
Keywords
-
Categories
Funding
- MRC [G9828345] Funding Source: UKRI
- Medical Research Council [G9828345] Funding Source: Medline
- Medical Research Council [G9828345] Funding Source: researchfish
Ask authors/readers for more resources
Extracellular matrix (ECM) molecules and growth factors have a crucial role in the signalling that controls cell behaviour during development. Integrins, which are cell-surface receptors for ECM molecules, and growth factor receptors cooperate with each other to regulate this signalling by several mechanisms. In particular, direct interactions between the integrin and growth factor receptors themselves, which often occur within a single macromolecular complex, amplify signalling by mechanisms that include posttranslational modifications and integrin shape changes that are related to activation. As a result,growth factor concentrations in the physiological range, which are too low to initiate signalling alone, do so in the presence of the ECM, enabling integrins to control the time and space of growth factor signalling.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available