Journal
LEUKEMIA RESEARCH
Volume 28, Issue 12, Pages 1303-1312Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2004.03.018
Keywords
generation of dendritic cells; fusion of autologous DC and AML blasts; autologous T cell proliferation; anti-leukemia immunity
Categories
Funding
- NCI NIH HHS [R01CA87057] Funding Source: Medline
Ask authors/readers for more resources
Presentation of AML antigens by dendritic cells DC could potentially induce a T cell-mediated anti-leukemic immune response. In the present study, we generated DC from adherent (AD-DC) and non-adherent (NAD-DC) myeloblasts obtained from bone marrows of AML patients. Both cell populations displayed morphological, phenotypic and functional properties of DC. The functions of NAD-DC were compared to AD-DC that had been fused with autologous AML blasts (FC/AML). The FC/AML induced greater T cell proliferation and CTL activity against autologous AML blasts (9/10 cases) as compared to NAD-DC. FC/AML may thus represent a promising strategy for DC-based immunotherapy of patients with AML. (C) 2004 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available