Journal
APPLIED PHYSICS LETTERS
Volume 95, Issue 25, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.3275577
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Funding
- ONR [ONR N001480810469]
- NIH [1R21EB009518, 1R01EB009764]
- ARO Institute for Collaborative Biotechnologies
- Armed Forces Institute for Regenerative Medicine (AFIRM)
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With a growing number of cell-based biotechnological applications, there is a need for particle separation systems capable of multiparameter separations at high purity and throughput, beyond what is presently offered by traditional methods including fluorescence activated cell sorting and column-based magnetic separation. Toward this aim, we report on the integration of microfluidic acoustic and magnetic separation in a monolithic device for multiparameter particle separation. Using our device, we demonstrate high-purity separation of a multicomponent particle mixture at a throughput of up to 10(8) particles/hr. (C) 2009 American Institute of Physics. [doi:10.1063/1.3275577]
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