Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 190, Issue 11, Pages 1936-1940Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/425516
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- NIAID NIH HHS [N01 AO 62712] Funding Source: Medline
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Respiratory syncytial virus (RSV) is an important cause of severe lower respiratory tract illness in infants and the elderly. Presently, no safe and efficacious RSV vaccine exists; however, advances in our understanding of immunity and the pathogenesis of disease associated with RSV infection may lead to new vaccine strategies. RSV G protein contains a CX3C chemokine motif that interacts with the CX3CR1 chemokine receptor and modifies the activities of fractalkine. In the present study, we show that anti-RSV G protein antibody responses after recent RSV infection or vaccination are associated with inhibition of RSV G protein CX3C-CX3CR1 interaction and RSV G protein-mediated leukocyte chemotaxis.
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