Journal
CELL CYCLE
Volume 3, Issue 12, Pages 1477-1480Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.3.12.1280
Keywords
NF-kappa B; epithelial-mesenchymal transition; metastasis; Ras; TGF-beta
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Activation of the transcription factor NF-kappaB occurs in many human tumors, and studies have shown that NF-kappaB can promote cell proliferation and oncogenesis, possibly by protecting cells from apoptosis. Little is known, however, about whether NF-kappaB is involved in tumor progression including epithelial-mesenchymal transition (EMT), a central process governing both morphogenesis and carcinoma progression in multicellular organisms. In a combined in vitro/in vivo model of mammary carcinogenesis, NF-kappaB was essential both for the induction and maintenance of EMT and for in vivo metastasis. NF-kappaB and the signaling pathways that are involved in its activation should therefore receive attention as potential targets for the development of novel anti-metastatic cancer treatments.
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