Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 37, Issue 11, Pages 1730-1735Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2004.08.003
Keywords
menopause; oxidative stress; diabetes; interleukin-6; heart disease; free radicals
Funding
- NIDDK NIH HHS [1R01 DK64797] Funding Source: Medline
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Postmenopausal diabetic women are at greater risk for heart disease compared with men of similar age and with other risk factors. We examined the hypothesis that 17beta-estradiol and trivalent chromium inhibit secretion of the pro-inflammatory cytokine interleukin (IL)-6 and oxidative stress in monocytes exposed to high glucose (HG). U937 human monocytes were cultured with HG (30 mM) with and without 17beta-estradiol (0-1000 nM) and chromium chloride (Cr3+, 0-10 muM) at 37degreesC for 24 h. Results show that beta-estradiol inhibits IL-6 and adhesion to endothelial cells (p < .05) by HG-treated monocytes. Treatment with 17beta-estradiol+Cr3+ required a significantly lower dose of estradiol-17beta compared with 17beta-estradiol alone for IL-6 inhibition. 17beta-Estradiol+Cr3+ also inhibited lipid peroxidation and the adhesivity to human endothelial cells in HG-treated monocytes. Thus, 17beta-estradiol+Cr3+ inhibits oxidative stress, IL-6 secretion, and monocytic adhesion to endothelial cells, risk factors in the development of heart disease. The female body requires E but studies on some patients indicate side effects with increased amounts of 17beta-estradiol-supplementation. The potential benefit of a lower estrogen dose in combination with chromium is novel and needs to be explored in postmenopausal diabetic women. (C) 2004 Elsevier Inc. All rights reserved.
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