Journal
ARCHIVES OF NEUROLOGY
Volume 61, Issue 12, Pages 1881-1884Publisher
AMER MEDICAL ASSOC
DOI: 10.1001/archneur.61.12.1881
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Funding
- NIA NIH HHS [U01 AG 06786, P50 AG 16574] Funding Source: Medline
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Background: Slowly progressive asymmetric parkinsonism and cortical dysfunction clinically characterize corticobasal syndrome (CBS). Various pathologic findings, including corticobasal degeneration (CBD), progressive supranuclear palsy, and frontotemporal degenerations, underlie CBS. Objective: To determine if regional cortical and corpus callosum atrophy and subcortical and periventricular white matter (SPWM) signal changes on head magnetic resonance imaging were specific to CBD. Design: Historical review of autopsy cases. Setting: Subspecialized behavioral neurology and movement disorder clinics within a neurology department of a tertiary referral center. Patients: Seventeen patients with CBS who had an antopsy-confirmed diagnosis of CBD or another neurodegenerative disease. Main Outcome Measures: Regional cerebral cortical atrophy, regional corpus callosum atrophy, and SPWM signal changes. Results: Similar patterns of regional atrophy and SPWM signal changes were found in the patients with autopsy-proven CBD and in the patients with other neurodegenerative diseases. Conclusion: Neither cortical nor corpus callosum atrophy nor SPWM signal changes on head magnetic resonance imaging are specific to CBD.
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