Journal
OBESITY RESEARCH
Volume 12, Issue -, Pages 163S-166SPublisher
NORTH AMER ASSOC STUDY OBESITY
DOI: 10.1038/oby.2004.283
Keywords
weight loss; sibutramine; orlistat; pharmacotherapy; behavior modification
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Obese patients unable to achieve significant weight loss with lifestyle changes alone may require drug therapy, and such therapy may be needed long term lest weight lost be regained. In the United States, only sibutramine and orlistat are available for the long-term treatment of obesity. Clinical trials have shown that both drugs can induce and maintain weight loss, even in patients with comorbid conditions such as hypertension or type 2 diabetes. Their use must be combined with behavior modification and a structured meal plan, however, for patients to reap the full benefits of such treatment.
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