Journal
AMERICAN JOURNAL OF HUMAN GENETICS
Volume 75, Issue 6, Pages 1143-1148Publisher
CELL PRESS
DOI: 10.1086/426405
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Funding
- NHGRI NIH HHS [HG01691] Funding Source: Medline
- NIMH NIH HHS [MH60240] Funding Source: Medline
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We have constructed de novo a high-resolution genetic map that includes the largest set, to our knowledge, of polymorphic markers (N = 14,759) for which genotype data are publicly available; that combines genotype data from both the Centre d'Etude du Polymorphisme Humain (CEPH) and deCODE pedigrees; that incorporates single-nucleotide polymorphisms; and that also incorporates sequence-based positional information. The position of all markers on our map is corroborated by both genomic sequence and recombination-based data. This specific combination of features maximizes marker inclusion, coverage, and resolution, making this map uniquely suitable as a comprehensive resource for determining genetic map information (order and distances) for any large set of polymorphic markers.
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