Inorganic delivery vector for intravenous injection

Uniform, small-sized (100-200nm), layered double hydroxides (LDH) were prepared by a conventional, wet chemistry method using different aging times of I and 3 days as an inorganic drug or gene delivery carrier. The samples prepared had a hexagonal thin, plate-like shape and TEM/SAD electron microscopy of LDH particles indicated that they were single crystals. In vivo testing of empty LDH administered to adult male Sprague Dawley rats was done to evaluate, the possibility of using LDH as an injectable drug delivery vehicle. (C) 2004 Elsevier Ltd. All rights reserved.