Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 37, Issue 11, Pages 1694-1702Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2004.08.027
Keywords
4-hydroxynonenal; cell signaling; protein kinase C; MAP kinases; tyrosine kinases; free radicals
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The interaction of 4-hydroxynonenal (HNE) with a variety of kinases variously involved in cell signaling is now a matter of active investigation. In particular, findings with regard to the effect of HNE on different components of the protein kinase C family and the mitogen-activated protein kinase complex already provide reliable indications of a potential role of this aldehyde as a cell signal messenger. Such a role appears further supported by the clear-cut evidence of up-regulation of receptor tyrosine kinases and down-regulation of the nuclear factor kappa B system, produced by FINE concentrations actually detectable in pathophysiology. (C) 2004 Elsevier Inc. All rights reserved.
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