Journal
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Volume 70, Issue 12, Pages 7520-7529Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.70.12.7520-7529.2004
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Funding
- NCI NIH HHS [CA83155, P01 CA083155] Funding Source: Medline
- NIAID NIH HHS [U01 AI048521, AI48521] Funding Source: Medline
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A unique selective enrichment procedure has resulted in the isolation and identification of two new genera of marine-derived actinobacteria. Approximately 90% of the microorganisms cultured by using the presented method were from the prospective new genera, a result indicative of its high selectivity. In this study, 102 actinomycetes were isolated from subtidal marine sediments collected from the Bismarck Sea and the Solomon Sea off the coast of Papua New Guinea. A combination of physiological parameters, chemotaxonomic characteristics, distinguishing 16S rRNA gene sequences, and phylogenetic analysis based on 16S rRNA genes provided strong evidence for the two new genera (represented by strains of the PNG1 clade and strain UMM518) within the family Micromonosporaceae. Biological activity testing of fermentation products from the new marine-derived actinomycetes revealed that several had activities against multidrug-resistant grant-positive pathogens, malignant cells, and vaccinia virus replication.
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