Journal
JOURNAL OF VIROLOGY
Volume 78, Issue 24, Pages 14048-14052Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.78.24.14048-14052.2004
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Funding
- NCRR NIH HHS [P51 RR000169, U51RR00169] Funding Source: Medline
- NIAID NIH HHS [R01 AI048484, U19 AI051596, R01 AI51596, P01 AI48484] Funding Source: Medline
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In rhesus macaques, classic systemic infection, characterized by persistent viremia and seroconversion, occurred after multiple low-dose (10(3) 50% tissue culture infective doses) intravaginal (IVAG) inoculations with simian immunodeficiency virus (SIV) strain SIVmac251. Monkeys developed classic SIV infections after a variable number of low-dose IVAG exposures to SIVmac251. Once established, the systemic infection was identical to SIV infection following high-dose IVAG SIV inoculation. However, occult systemic infection characterized by transient cell-associated or cell-free viremia consistently occurred early in the series of multiple vaginal SIV exposures. Further, antiviral cellular immune responses were present prior to the establishment of a classic systemic infection in the low-dose vaginal SIV transmission model.
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