Journal
DIAGNOSTIC CYTOPATHOLOGY
Volume 31, Issue 6, Pages 392-396Publisher
WILEY
DOI: 10.1002/dc.20156
Keywords
immunostaining; galectin-3; CD44v6; aspiration cytology; thyroid follicular tumor
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To evaluate the clinical applicability of galectin-3 and CD44 variant 6 (CD44v6) inummostaining in fine-needle aspiration cytology (FNAC) of thyroid follicular tumors, 79 cytological specimens (35 follicular carcinomas and 44 follicular adenomas) were studied. The positive rates of galectin-3 and CD44v6 were 89 and 74% in follicular carcinoma, respectively, and 25 and 30% in follicular adenoma, respectively. There were no significant correlations between the expression of galectin-3 or CD44v6 in follicular carcinoma and characteristics such as capsular invasion, vascular invasion, metastasis, or tumor size. Positive staining of either galectin-3 or CD44v6 resulted in a diagnostic sensitivity of 97% and a specificity of 52% for follicular carcinoma among follicular tumors. Immunostaining of galectin-3 or CD44v6 using cytological specimens can provide independent information on conventional morphological findings of cytology to distinguish follicular carcinoma from adenoma. (C) 2004 Wiley-Liss, Inc.
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